Pilot study: Vitamin D improves mood, blood pressure in women with diabetes

MAYWOOD, Ill. — In women who have Type 2 diabetes and show signs of depression, vitamin D supplements significantly lowered blood pressure and improved their moods, according to a pilot study at Loyola University Chicago Niehoff School of Nursing released Tuesday. The study was presented at the American Diabetes Association 73rd Scientific Sessions in Chicago.

Vitamin D even helped the women lose a few pounds.

“Vitamin D supplementation potentially is an easy and cost-effective therapy, with minimal side effects,” stated Sue Penckofer, lead author of the study and a professor in the Niehoff School of Nursing. “Larger, randomized controlled trials are needed to determine the impact of vitamin D supplementation on depression and major cardiovascular risk factors among women with Type 2 diabetes.”

Penckofer recently received a four-year, $1.5 million grant from the National Institute of Nursing Research at the National Institutes of Health to do such a study. Penckofer and her Loyola co-investigators plan to enroll 180 women who have Type 2 diabetes, symptoms of depression and insufficient levels of vitamin D. Women will be randomly assigned to receive either a weekly vitamin D supplementation (50,000 International Units) or a matching weekly placebo for six months. The study is titled “Can the Sunshine Vitamin Improve Mood and Self Management in Women with Diabetes?"

The pilot study included 46 women who were an average age of 55 years, had diabetes an average of 8 years and insufficient blood levels of vitamin D (18 ng/ml). They took a weekly dose (50,000 International Units) of vitamin D. By comparison, the recommended dietary allowance for women 51 years to 70 years is 600 IU per day.

After six months, their vitamin D blood levels reached sufficient levels (average 38 ng/mL), and their moods improved significantly. For example, in a 20-question depression symptom survey, scores decreased from 26.8 at the beginning of the study, indicating moderate depression, to 12.2 at six months, indicating no depression.

Blood pressure also improved, with the upper number decreasing from 140.4 mm Hg to 132.5 mm Hg. And their weight dropped from an average of 226.1 lbs to 223.6 lbs.